Mix l. Validation of Analytical Procedures 3. Batch Analyses 3. The differences in requirements for new or existing active substances are clarified in the relevant paragraphs of the guideline where applicable. For the purposes of this guideline, an existing training. Supplement 1 — March 1, Supplement changes from the 10th Edition that failed to appear in the 11th Edition and errata from the publishing of the11th Edition.
For the chemicals being used general information about them i. The procedure for the preparation has been provided in detail. Precautions to be followed concerning safety and otherwise along with storage and handling tips are … Reagent Chemicals: Specifications and Procedures : American Chemical Society Specifications, Official from January 1, Committee on Analytical Reagents.
American Chemical Society, — Science — pages. The ACS Committee on Analytical Reagents sets purity specifications for almost reagent chemicals and over standard-grade reference materials. These specifications have become the de facto standards for chemicals used in many high-purity applications, with agencies like the US EPA and ASTM referencing these specifications and methods. In addition […] Books reagent chemicals specifications and procedures american chemical society committee on analytical reagents PDF, ePub, Mobi Page 1 reagent chemicals specifications and procedures american chemical society committee on Derivatization Reactions and Reagents for Gas Reagents Indicators and Solutions drugfuture.
Grades of Chemicals General Reagent A. A Certificate of Analysis is available upon request. We offer a vast range of quality chemicals and reagents. Whether you are analysing environmental samples, conducting routine testing or using analytical instruments, our extensive range will allow you to select the right chemical for your application. When the ACS Committee on Analytical Reagents first began its work, one of its missions was to bring order and comparability of results to reagent analysis.
The Committee set specifications and tests according to the principle that all tests must be performed with procedures that were commonly available to producers and users.
Over the years, the Committee has participated in a definite shift toward instrumental methods of analysis that improve test methods and suit current laboratory practices. The specifications of reagent chemicals can be divided into two main classes: an assay or quantitative determination of the principal or active constituent and the determination of the impurities or minor constituents. The specifications of standard-grade reference materials are divided into identity and assay sections.
In some cases, physical properties are specified. A method validation process must demonstrate-with evidence to a high degree of assurance-that a specific method will consistently perform according to its intended specified purpose.
It is the policy of the ACS Committee on Analytical Reagents to validate any new method described in an individual monograph that is published in or after the Tenth Edition. Analytical methods published in the Ninth Edition or earlier have been tested and proven by both intra- and interlaboratory verifications and will be accepted retrospectively as validated. Major modifications made to existing methods from the Ninth Edition or earlier that are incorporated into editions after the Tenth Edition or published in supplements to later editions will be validated according to the new policy.
The purity of reagent chemicals and standard-grade reference materials continues to improve, driven by customer demand and the evolution of manufacturing processes and analytical technology. A clear and practical definition of analytical detection limits is vital to the accurate and precise determination of purity. An excellent review and definition of detection limits has been published.
This reference provides other details, including the use of control charts to measure and monitor the accuracy and precision of any analytical procedure. In case the limit of detection of trace metal impurities in ultratrace reagents needs to be determined, a more relevant method has been published and is recommended. The descriptions of the individual tests are intended to give all essential details without repetition of considerations that should be obvious to an experienced analyst.
A few suggestions are given for precautions and procedures that are particularly applicable to the routine testing of reagent chemicals. In many of the reagent monographs, it is directed that a precipitate or residue be collected and either dried or ignited so as to provide certain information concerning the purity of the reagent.
Except where it is directed otherwise in the specific reagent tests, the following directions and precautions will be used in collecting, drying, and igniting precipitates and residues. In titrimetry, materials or groups of materials are quantified by measuring the volume of a reagent solution with known concentrations of a substance, the titrimetric solution. The titrimetric solution is used for a defined, complete chemical conversion with the materials that are to be measured.
Adding a reagent until one can recognize the end point of the reaction is known as titration. The reagent is called the titrant, and the material to be tested is the sample or analyte. The chemical conditions that are required as a prerequisite for each titrimetric determination are a defined course of the reaction between the sample and the titrant and the ability to recognize the equivalence point or titration end point.
This paragraph is adapted, with permission, from Schwedt, Conditions and quantities for colorimetric or turbidimetric tests have been chosen to produce colors or turbidities that can be observed easily. These conditions and quantities approach but do not reach the minimum that can be observed. Five minutes, unless some other time is specified, must be allowed for the development of the colors or turbidities before the comparisons are made.
If solutions of samples contain any turbidity or insoluble matter that might interfere with the later observation of colors or turbidities, they must be filtered before the addition of the reagent used to produce the color or turbidity.
Under Polarographic Analysis, various techniques are defined including direct current dc , differential pulse dp , square wave sqw , and stripping voltammetry. The determination of individual elements can be performed by a number of atomic spectroscopic AS techniques, which differ mainly in their sensitivity, selectivity, sample throughput capability, and cost. The trace element techniques used in this book for measuring the purity of reagent chemicals include atomic absorption spectroscopy AAS , inductively coupled plasma—optical emission spectroscopy ICP—OES , and inductively coupled plasma—mass spectrometry ICP—MS.
Atomic absorption is still recommended for a group of alkali, alkaline earth, and transition elements, whereas plasma emission spectroscopy is now being phased in as the technique of choice for the determination of trace metal impurities in most of the reagent chemicals. It should also be emphasized that many laboratories are now using inductively coupled plasma—mass spectrometry for ultratrace metal determinations. Not only does this rapid multi-element technique have much lower detection limits than the other AS techniques, but also it offers the exciting capability of isotopic measurements.
Chromatography is an analytical technique used in the quantitative determination of the purity of most organic and an increasing number of inorganic reagent chemicals and standard-grade reference materials. The broad scope of chromatography allows it to be used in the separation, identification, and assay of diverse chemical species, ranging from simple metal ions to compounds of complex molecular structure, such as proteins.
In chromatography, the separation of individual components in a mixture is achieved when a mobile phase is passed over a stationary phase. Differences in affinities of various substances for these phases result in their separation. Chromatography can be divided into two main branches, depending on whether the mobile phase is a gas or a liquid. Gas chromatography is principally used for analysis of volatile, thermally stable materials.
Liquid chromatography is particularly useful for analysis of nonvolatile or thermally unstable organic substances. Ion chromatography, a technique in which anions and cations can be determined by using the principles of ion exchange, is a form of liquid chromatography. Thin-layer chromatography, often called planar chromatography, is also a form of liquid chromatography.
Infrared IR spectroscopy is an absorption method widely used in both qualitative and quantitative analyses. The infrared region of the spectrum includes electromagnetic radiation that can alter the vibrational and rotational states of covalent bonds in organic molecules.
The IR spectrum of an organic compound is a unique physical property and can be used to identify unknowns by interpretation of characteristic absorbances and comparison with spectral libraries. IR spectroscopy is also used in quantitative techniques because of its sensitivity and selectivity. It can be used to quantitate analytes in complex mixtures and is used extensively in detection of industrial pollutants in the environment.
The IR technique is discussed here primarily for application in identification of organic compounds and will focus on the mid-infrared region. Instrumental operating procedures are not given because they will vary depending on instrument design.
A brief discussion of the theory will be followed by a discussion of instrumentation, sample handling techniques, and qualitative analysis. The tests and limits in the monographs are based on the use of the solutions in the strength indicated below.
Wherever the use of ammonium hydroxide or an acid is prescribed with no indication of strength or dilution, the reagent is to be used at full strength as described in its monograph.
Dilutions are indicated either by the percentage of some constituent or by the volumes of reagents and water mixed to prepare a dilute reagent. Dilute acid or ammonium hydroxide 1:x means a dilute solution prepared by mixing 1 volume of the strong acid or ammonium hydroxide with x volumes of reagent water.
Unless otherwise indicated, the reagent solutions are prepared and diluted with reagent water by using standard class A volumetric pipettes and flasks. Weights are measured on a four-place calibrated balance. Many of the tests for impurities require comparison of the color or the turbidity produced under specified conditions by an impurity ion with the color or the turbidity produced under similar conditions by a known amount of the impurity.
Three types of solutions are used to determine the amounts of impurities in reagent chemicals: blank, standard, and control. Various textbooks on chemical analysis also deal with volumetric solutions and volumetric analysis on both a theoretical and a practical basis. This monograph for Acetaldehyde provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Residue after Evaporation, and Titrable Acid.
This monograph for Acetic Acid, Glacial provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and pKa.
This monograph for Acetic Acid, Ultratrace provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and pKa.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Chloride, Sulfate, Mercury, and Trace Metals.
This monograph for Acetic Anhydride provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density. CH3CO 2O. This monograph for Acetone provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density.
CH3 2CO. This monograph for Acetonitrile provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and pKa.
This monograph for Acetyl Chloride provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density. This monograph for Aluminum provides, in addition to common physical constants, a general description including typical appearance, applications, and change in state approximate. This monograph for Aluminum Ammonium Sulfate Dodecahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Aluminum Nitrate Nonahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Aluminum Potassium Sulfate Dodecahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Aluminum Sulfate, Hydrated provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for 4-Aminoantipyrine provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Sensitivity to Phenol, Residue after Ignition, and Loss on Drying. This monograph for 2-Aminoethanol provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, density, and pKa.
This monograph for 4-Aminohydroxynaphthalene Sulfonic Acid provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Solubility in Sodium Carbonate, Residue after Ignition, Sulfate, and Sensitivity to Phosphate.
This monograph for Ammonium Acetate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Ammonium Benzoate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Ammonium Bromide provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Ammonium Carbonate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
CAS No. This monograph for Ammonium Chloride provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Ammonium Citrate, Dibasic provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility.
This monograph for Ammonium Dichromate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. NH4 2Cr2O7. This monograph for Ammonium Fluoride provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Ammonium Hydroxide provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Ammonium Hydroxide, Ultratrace provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Chloride, Phosphate, Sulfate, Mercury, and Trace Metals.
This monograph for Ammonium Iodide provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Ammonium Metavanadate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Solubility in Ammonium Hydroxide, Carbonate, Chloride, and Sulfate. This monograph for Ammonium Molybdate Tetrahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Ammonium Nitrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Ammonium Oxalate Monohydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Ammonium Peroxydisulfate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
NH4 2S2O8. This monograph for Ammonium Phosphate, Dibasic provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. NH4 2HPO4. This monograph for Ammonium Phosphate, Monobasic provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Ammonium Sulfamate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Ammonium Sulfate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
NH4 2SO4. This monograph for Ammonium Sulfide Solution provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Residue after Ignition, Carbonate, and Chloride.
NH4 2S. This monograph for Ammonium Thiocyanate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Aniline provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, density, and pKa. This monograph for Anthrone provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Melting Point, Sensitivity to Carbohydrates, Absorbance of Reagent Solution, and Solubility in Ethyl Acetate. This monograph for Antimony Trichloride provides, in addition to common physical constants, a general description including typical appearance, applications, and change in state approximate.
This monograph for Arsenic Trioxide provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. Special caution is advised for the handling or testing of this substance. This monograph for Ascorbic Acid provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Aurin Tricarboxylic Acid, [tri]Ammonium Salt provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Sensitivity to Aluminum, Insoluble Matter, and Residue after Ignition. This monograph for Barium Acetate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Barium Carbonate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Barium Chloride Dihydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Barium Diphenylamine Sulfonate provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Residue after Ignition, Clarity of Solution, and Sensitivity as Redox Indicator. This monograph for Barium Hydroxide Octahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Barium Nitrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. Ba NO3 2. This monograph for Bathocuproine provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Melting Point, Clarity of Solution, and Sensitivity to Copper.
This monograph for Benzene provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density. This monograph for 1,3-Benzenediol provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density.
C6H4 OH 2. This monograph for Benzoic Acid provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, density, and pKa. This monograph for Benzoyl Chloride provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density.
This monograph for Benzyl Alcohol provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Melting Point, Clarity, Absorbance of Solution, and Sensitivity to Ferrous Iron.
This monograph for Bismuth Chloride provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Bismuth Nitrate Pentahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility.
This monograph for Boric Acid provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and pKa. This monograph for Bromine provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Bromocresol Green provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Clarity of Solution and Visual Transition Interval.
C21H14Br4O5S sultone. This monograph for Bromocresol Purple provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. C21H16Br2O5S sultone. This monograph for Bromphenol Blue provides, in addition to common physical constants, a general description including typical appearance, typical appearance, applications, change in state approximate , and aqueous solubility.
C19H10Br4O5S sultone. This monograph for Bromthymol Blue provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. C27H28Br2O5S sultone. This monograph for Brucine Sulfate Heptahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Sensitivity to Nitrate, Clarity of Solution, Loss on Drying, and Residue after Ignition.
This monograph for 2-Butanone provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density. This monograph for n-Butyl Acetate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density.
This monograph for Butyl Alcohol provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density. This monograph for tert-Butyl Alcohol provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , aqueous solubility, and density.
CH3 3COH. This monograph for Cadmium Chloride, Anhydrous provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Cadmium Chloride, Crystals provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Cadmium Nitrate Tetrahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Cadmium Sulfate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Calcein provides, in addition to common physical constants, a general description including typical appearance and applications.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Clarity of the Solution and Suitability for Calcium Titration. This monograph for Calcium Acetate Monohydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Calcium Carbonate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Calcium Carbonate, Chelometric Standard provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Calcium Carbonate, Low in Alkalis provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Calcium Chloride Desiccant provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay and Titrable Base.
This monograph for Calcium Chloride Dihydrate provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility. This monograph for Calcium Hydroxide provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility. Ca OH 2. This monograph for Calcium Nitrate Tetrahydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility.
This monograph for Calcium Sulfate Dihydrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state approximate , and aqueous solubility. This monograph for Calmagite provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Clarity of Solution and Suitability for Complexometric Titration.
Safeguard products by complying with requirements from governing body organizations. Government organizations : Make it easier for researchers to employ well-established methods that produce reliable, repeatable results. All content is under constant review by the ACS Committee on Analytical Reagents and subscription fees include regular updates and additions that typically take place twice each year Emergent updates Free e-alerts notifying users of updated content Summary of updates and changes going back to and moving forward.
Mobile-friendly operation Live links between reagents and methods HTML or printable PDF formats Permanent URLs to the current version A quick-glance summary of historic changes and available versions Full-text and keyword searching Highlights for safety issues, handling requirements, and stock solution preparations Clickable, copiable equations that provide easy transfer.
Get full-text access ACS Reagent Chemicals is a database-style reference that is constantly maintained for currency and authority. It has recipes for common reagents in the tests—very helpful.
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