Epstein barr virus lysine

In some cases, though, environmental triggers, including stress or coincident infections and immune suppression, create conditions in which the virus can thrive, occasionally sparking a rare type of lymphoma or other cancer. Four years ago, the U of U Health research team found that spironolactone, a medicine routinely used to treat heart failure, has an unexpected antiviral activity against EBV. Several years ago, a group of French researchers found that spironolactone degrades a host protein called XPB, which plays an important role in cellular transcription — one of the first steps in gene expression.

Following up on this lead, Swaminathan and his colleague Dinesh Verma conducted a series of experiments to explore the potential link between the two proteins that the drug interacts with, XPB and SM.

The researchers first used a molecular biology technique to specifically lower the amount of XPB in host cells. Tsurumi T. Latent and lytic Epstein-Barr virus replication strategies. Gruffat H. Manet E. Nucleic Acids Res. Chang L. Robinson A. Darr C. Lee Y. Flemington E. Identification of phorbol ester response elements in the promoter of Epstein-Barr virus putative lytic switch gene BZLF1.

Daibata M. Liu S. Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member. Nawandar D. Sun C. Wang Y. Kraus R. Iempridee T. Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene.

Liu P. Guo R. Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Glaser G. Reusch J. Sarkar R. Egr-1 regulates RTA transcription through a cooperative involvement of transcriptional regulators. Zalani S. Han Z. Multiple roles of Epstein-Barr virus SM protein in lytic replication. Juillard F. Key S. Nicewonger J. Ruvolo V. Verma D. Fixman E. Replication of Epstein-Barr virus oriLyt: Lack of a dedicated virally encoded origin-binding protein and dependence on Zta in cotransfection assays.

Schepers A. Chakravorty A. Aubry V. Watanabe T. Sato Y. Regulation of Epstein-Barr virus reactivation from latency.

Lee C. Fernandez A. Genome Res. Johannsen E. Proteins of purified Epstein-Barr virus. Ichikawa T. Tsai K. Viral Reprogramming of the Daxx Histone H3. Alinari L. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.

Leonard S. Liu C. Modulation of Epstein—Barr Virus Nuclear Antigen 2-dependent transcription by protein arginine methyltransferase 5. Shire K. Hansen K. Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization. Hernando H. Epstein—Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation. The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion.

Genome Biol. Stanland L. Kaneda A. Epstein-Barr virus infection as an epigenetic driver of tumorigenesis. Pott S. What are super-enhancers? Jiang S. Cell Host Microbe. Zhou H. Gunnell A. Hosoi H. Frost T. Epigenetic crossroads of the Epstein-Barr virus B-cell relationship. Hutchings I. Park J. Wp specific methylation of highly proliferated LCLs. Robertson K. Schaefer B.

Host-cell-determined methylation of specific Epstein-Barr virus promoters regulates the choice between distinct viral latency programs. Tao Q. The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive. Falk K. Methylation and expression of Epstein-Barr virus latent membrane protein 1, 2A and 2B in EBV-associated gastric carcinomas and cell lines.

Liver Dis. Herold M. CTCF: Insights into insulator function during development. Hnisz D. Tempera I. Arvey A. Epigenetic regulation of EBV persistence and oncogenesis. Day L. Imai K. Role of the histone H3 lysine 9 methyltransferase Suv39 h1 in maintaining Epsteinn-Barr virus latency in B cells. FEBS J. Ramasubramanyan S. Bivalent Histone Modifications and Development. Stem Cell Res. Djavadian R. Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis.

Latency and lytic replication in Epstein—Barr virus-associated oncogenesis. Munz C. Katsumura K. Kimura H. Okuno Y. Defective Epstein—Barr virus in chronic active infection and haematological malignancy.

Martini M. Tong J. Cancer Inst. Bristol J. Palser A. Venturini C. Lin X. Stuart A. The Epstein-Barr virus encoded cytokine viral interleukin enhances transformation of human B lymphocytes. Suzuki M. The heat shock protein 90 inhibitor BIIB suppresses the growth of T and natural killer cell lymphomas. Iwata S. Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells.

Cancer Sci. Siddiquey M. Anti-tumor effects of suberoylanilide hydroxamic acid on Epstein—Barr virus-associated T cell and natural killer cell lymphoma. Nishikawa J. Chan A. Dalton T. Yiu S. Ghosh S. Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. Support Center Support Center. External link. Please review our privacy policy.

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